Transcriptome analysis of bladder urothelium from control and Utx-deficient mice with wild-type or heterozygous for p53.

UTX (Ubiquitously transcribed tetratricopeptide repeat, X chromosome, also known as KDM6A) mutations are frequently found in urologic tumors including BC, strongly suggesting that UTX plays fundamental roles in the homeostasis of the urinary system. However, the molecular mechanisms through which functional loss of UTX contributes to BC pathogenesis remain to be fully clarified. To address this issue, we generated mice with bladder urothelium-specific deletion of UTX. In addition, to analyze the multistep process of BC carcinogenesis, the Utx-deficient mice were crossed with heterozygous mice for p53, whose mutation/deletion is frequently overlapped with Utx mutation, and were exposed to BBN.