Co-structure of Main Protease of SARS-CoV-2 (COVID-19) with covalent inhibitor

NIAID Data Ecosystem2026-05-02 收录

新冠病毒药物靶点

共价抑制剂设计

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资源简介：

Co-structure of Main Protease of SARS-CoV-2 (COVID-19) with covalent inhibitor

创建时间：

2024-10-23

Crystal structure of ITK in complext with compound 40

蛋白激酶结构

共价抑制剂设计

Crystal structure of ITK in complext with compound 40 Descriptor: 3-{4-amino-1-[(3R)-1-propanoylpiperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-N-[4-(propan-2-yl)phenyl]benzamide, Tyrosine-protein k

Protein Data Bank Japan2024-10-30 更新90

Structure of SARS-CoV-2 3CL protease in complex with inhibitor 11c

新冠病毒药物靶点

基于结构的药物设计

Structure of SARS-CoV-2 3CL protease in complex with inhibitor 11c Descriptor: (1R,2S)-2-[(N-{[(7-cyano-7-azaspiro[3.5]nonan-2-yl)oxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]p

Protein Data Bank Japan2024-11-20 更新50

Discovery of a New-Generation S‑Adenosylmethionine-Noncompetitive Covalent Inhibitor Targeting the Lysine Methyltransferase Enhancer of Zeste Homologue 2

共价抑制剂设计

EZH2表观遗传靶点

The first-generation enhancer of zeste homologue 2 (EZH2) inhibitors suffer from several limitations, such as high dosage, cofactor S-adenosylmethionine (SAM) competition, and acquired drug resistance

Figshare2023-05-19 更新30

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with PCM-0102353

新冠病毒药物靶点

X射线晶体学

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 main protease in complex with PCM-0102353

NIAID Data Ecosystem60

Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 obtained in presence of 500 micromolar X77 enantiomer S.

新冠病毒药物靶点

抑制剂结构

Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 obtained in presence of 500 micromolar X77 enantiomer S.

NIAID Data Ecosystem30