Differences in biliopancreatic duct development exist in Type I congenital biliary dilatation based on microarray expression analysis of mRNAs and long noncoding RNAs

Congenital biliary dilatation (CBD) is a malformation presenting extra- and/or intrahepatic dilatation bile ducts and often associated with pancreaticobiliary maljunction. Different types of CBD have been noted clinical differences. LncRNA and mRNA sequencing and bioinformatics analysis in CBD can help us to further study the pathogenesis of different types of CBD at the genetic level in the context of clinical data. Overall design: Thirty-six patients with Congenital biliary dilatation (CBD) (eighteen cystic and eighteen fusiform) were consecutively recruited between October 2019 and December 2021 from the Pediatric Surgery Department of West China Hospital, Sichuan University. All children were diagnosed clinically according to medical history and imaging such as hepatobiliary ultrasonography and magnetic resonance cholangiopancreatography and underwent cyst excision and Roux-Y hepaticojejunostomy. Extrahepatic dilatations were collected, and all specimens were stored in liquid nitrogen after excision.