Iridium(III)-Catalyzed C‑7 Selective C–H Alkynylation of Indolines at Room Temperature

An
iridium-catalyzed direct C-7 selective C–H alkynylation
of indolines at room temperature, for the first time, has been developed
via C–H bond activation. Furthermore, the first example of
direct C–H alkynylation of carbazoles at the C1 position is
also achieved. More importantly, the resulting product can be readily
transformed into C7-alkynylated indoles, further widening the C-7
derivatization of indoles and highlighting the synthetic utility of
this methodology.