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EZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation

NIAID Data Ecosystem2026-03-09 收录

非霍奇金淋巴瘤治疗

EZH2抑制剂

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA263117 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2014-10-04

黑色素瘤分子标志物

EZH2抑制剂

Although gene mutations and aberrant chromosomes are associated with the pathogenesis and prognosis of uveal melanoma (UM), potential therapeutic targets still need to be explored. We aim to determine

NIAID Data Ecosystem30

Expression analysis after EZH1,2 inhibition in lymohoma cells. Expression analysis after EZH1,2 inhibition in lymohoma cells

淋巴瘤基因表达

EZH2抑制剂

To define gene expression alteration by EZH1/2 ihibition, we performed gene expression profiling in lymphoma cells after treatment of inhibitors or shRNAs Overall design: Total RNA samples from lympho

NIAID Data Ecosystem30

Lineage specific canonical and non-canonical EZH2 activity in advanced prostate cancer subtypes [RNA-Seq]

前列腺癌分子机制

EZH2抑制剂

Inhibiting EZH2 using tazemetostat led to induction of lineage-specific genes Overall design: Tazemetostat treated PRAD and NEPC samples.

NIAID Data Ecosystem10

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2 H )‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

EZH2抑制剂

肿瘤药物研发

A new enhancer of zeste homolog 2 (EZH2) inhibitor series comprising a substituted phenyl ring joined to a dimethylpyridone moiety via an amide linkage has been designed. A preferential amide torsion

NIAID Data Ecosystem30

The Importance of Being Me: Magic Methyls, Methyltransferase Inhibitors, and the Discovery of Tazemetostat

组蛋白甲基化抑制剂

EZH2抑制剂

Posttranslational methylation of histones plays a critical role in gene regulation. Misregulation of histone methylation can lead to oncogenic transformation. Enhancer of Zeste homologue 2 (EZH2) meth

NIAID Data Ecosystem20

EZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation

资源简介：

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