Pooled CRISPR screens in human intestinal organoids [CUT&RUN]
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
We performed CRISPR screens on both a sub-library and a genome-wide scale in human intestinal organoids to discover cancer driver genes. We investigated the Wnt and the TGFB pathway and used both WT, APC-mutant and APC-TP53-mutant organoids. Overall design: To investigate how the identified SWI/SNF screening hits confer TGFB resistance, we assessed changes in binding of SMAD3 to the chromatin upon ARID1A or SMARCA4 perturbation and TGFB treatment
创建时间：
2020-05-06
