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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

NIAID Data Ecosystem2026-05-02 收录

流感疫苗研发

神经氨酸酶抑制

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A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

应用场景：

创建时间：

2024-11-06

流感疫苗研发

病毒进化分析

Data are the result of the analysis of similarity of Influenza H5N1 virus based on H5 hemagglutinin amino acid sequence available – full length and globular domain. The dataset contains A) lists of th

Figshare2023-10-17 更新80

Characterization of influenza H5Nx Candidate Vaccine Viruses formulations

流感疫苗研发

病毒免疫原性分析

We presented data on the production and characterization of three distinct monovalent antigens of H5Nx Candidate Vaccine Viruses (CVVs) from clades 2.3.2.1c (NIBRG-301), 2.3.4 (IBCDC-RG6), and 2.3.4.4

Figshare2024-11-20 更新30

Hemagglutinin (HA1) mutations specific to isolates with reduced zanamivir sensitivity.

流感病毒抗药性

神经氨酸酶抑制

Each 2009 isolate was sequenced directly following three passages in MDCK cells, without plaque purification. Sequence heterogeneities were observed at some locations and alternate amino acids at such

NIAID Data Ecosystem30

Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice

流感疫苗研发

交叉免疫反应

Annual immunization against influenza virus is a large international public health effort. Accumulating evidence suggests that antibody mediated cross-reactive immunity against influenza hemagglutinin

NIAID Data Ecosystem50

Structural and Functional Analysis of Anti-Influenza Activity of 4‑, 7‑, 8- and 9‑Deoxygenated 2,3-Difluoro‑N‑acetylneuraminic Acid Derivatives

流感疫苗研发

抑制剂设计

Competitive inhibitors of the influenza neuraminidase (NA) were discovered almost 20 years ago, with zanamivir and oseltamivir licensed globally. These compounds are based on a transition state analog

Figshare2018-02-15 更新30

A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES

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