GOLGI ALPHA-MANNOSIDASE II in complex with 5-(Adamantan-1yl-methoxy)-pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide

GOLGI ALPHA-MANNOSIDASE II in complex with 5-(Adamantan-1yl-methoxy)-pentyl 2,5-dideoxy-2,5-imino-D-talo-hexonamide Descriptor: (2~{S},3~{R},4~{S},5~{R})-~{N}-[5-(1-adamantylmethoxy)pentyl]-5-(hydroxymethyl)-3,4-bis(oxidanyl)pyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... Authors: Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. Deposit date: 2019-05-20 Release date: 2020-07-08 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020高尔基体α-甘露糖苷酶II（Golgi Alpha-Mannosidase II）与5-(1-金刚烷基甲氧基)戊基2,5-二脱氧-2,5-亚氨基-D-塔罗己酰胺的复合物，其结构描述符为：(2S,3R,4S,5R)-N-[5-(1-金刚烷基甲氧基)戊基]-5-(羟甲基)-3,4-二羟基吡咯烷-2-甲酰胺、1,2-乙二醇、α-甘露糖苷酶2……作者：Armstrong Z、Lahav D、Johnson R、Kuo C.L、Beenakker T.J.M、de Boer C、Wong C.S、van Rijssel E.R、Debets M、Geurink P.P、Ovaa H、van der Stelt M、Codee J.D.C、Aerts J.M.F.G、Wu L、Overkleeft H.S、Davies G.J。入库日期：2019-05-20；发布日期：2020-07-08；最后修改日期：2024-10-09。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.95埃。引用文献：《Manno-表-环壳醇类实现人类α-甘露糖苷酶的活性导向蛋白质谱分析及新型高尔基体甘露糖苷酶II抑制剂的发现》，刊载于《美国化学会志》（J. Am. Chem. Soc.），2020年，第142卷。