Multi-omics datasets in people living with HIV (2000HIV study)

In this collection, you can find the following datasets from the 2000HIV cohort: (1) gene counts (bulk transcriptomic data), (2) ex vivo cytokine data upon stimulation, (3) pre-imputed genetic data, (4) normalized metabolomics data, (5) methylation data from whole blood, and a (6) selection of phenotype data.

The 2000HIV study is a prospective longitudinal cohort study of people living with HIV (PLHIV) on cART. It aims to study the determinants of inter-individual variation in PLHIV, discover new biological pathways, and identify biomarkers that play a role in persistent inflammation, accelerated aging, non-AIDS comorbidities, extreme HIV-related clinical phenotypes (Elite controllers, immunological non-responders, and rapid progressors) and the HIV viral reservoir size and composition. To this end, 1895 PLHIV, divided into two independent cohorts (a discovery and a validation cohort), recruited between 2019 and 2021 and followed up for two years. Extensive clinical data and measurements were registered, multi-omics data were generated, and the latent viral reservoir size and composition were assessed in this cohort. Within this study, multi-omics integration was performed to identify the drivers of variation and their influence on immune responses in PLHIV.