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Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP

NIAID Data Ecosystem2026-05-01 收录

疟原虫靶点结构

耐药性突变体复合物

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Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP

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创建时间：

2023-11-22

疟原虫靶点结构

蛋白质-配体复合物

A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1 Descriptor: 4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde, Enoyl-ACP reductase, NICOTINAMIDE

Protein Data Bank Japan2023-11-01 更新50

Structure of Plasmodium vivax phosphoglycerate kinase

疟原虫靶点结构

抗疟药物设计

Structure of Plasmodium vivax phosphoglycerate kinase Descriptor: BROMIDE ION, POTASSIUM ION, Phosphoglycerate kinase Authors: Blaszczyk, B.K, Hyvonen, M. Deposit date: 2020-02-17 Release date: 2020-0

Protein Data Bank Japan2024-01-24 更新30

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

抗疟药物研发

疟原虫靶点结构

A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal chemistry program. Structur

NIAID Data Ecosystem20

Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z287256168

疟原虫靶点结构

蛋白质-配体复合物

Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z287256168

NIAID Data Ecosystem40

Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP

疟原虫靶点结构

抗疟药物设计

Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-amino-5-

Protein Data Bank Japan2023-09-06 更新30

Crystal structure of quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum DHFR-TS complexed with BT3, NADPH, and dUMP

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