ERAP1 in complex with (3R,4R)-1-(3-cyano-6-methylpyridin-2-yl)-4-(propan-2-yl)pyrrolidine-3-carboxylic acid

ERAP1 in complex with (3R,4R)-1-(3-cyano-6-methylpyridin-2-yl)-4-(propan-2-yl)pyrrolidine-3-carboxylic acid Descriptor: (3R,4R)-1-(3-cyano-6-methyl-pyridin-2-yl)-4-propan-2-yl-pyrrolidine-3-carboxylic acid, 1,2-ETHANEDIOL, Endoplasmic reticulum aminopeptidase 1, ... Authors: Rowland, P. Deposit date: 2025-11-26 Release date: 2026-07-08 Last modified: 2026-07-22 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Discovery of an Orally Available Potent ER Aminopeptidase 1 (ERAP1) Inhibitor That Enhances Antitumor Responses and Limits Inflammatory Autoimmunity In Vivo . J.Med.Chem., 69, 2026