Sensitive Electrochemical Sensors for Glucose Detection Based on Ni(OH)2/Nickel-Dimethylglyoxime Composite Nanotubes (Supporting Information)

Eectrochemical glucose sensors is crucial for both environmental and human health, requiring rational nanoarchitectures with high electrochemical performance for glucose oxidation. Ni(OH)2/Ni(DMG)2 composite nanotubes were synthesized by etching nickel-dimethylglyoxime (DMG) nanorods with OH−, using Ni(DMG)2 as a partially sacrificial template. The optimal Ni(OH)2/Ni(DMG)2 nonenzymatic glucose sensor was evaluated on both conventional and portable electrochemical workstations, showing high sensitivity and a low detection limit. The optimal Ni(OH)2/Ni(DMG)2 glucose sensors integrated into smartphones demonstrated a low detection limit of 3.3 µM (M = mol L−1), a wide linear range (10 µM–8 mM), and a sensitivity of 262.80 µA mM−1 cm−2 for glucose detection. The sensors also exhibited favorable stability and reproducibility, along with preferable resistance to interference in the presence of uric acid, gluconate, proline, NaCl, valine, and lysine. Moreover, the portable sensor also demonstrated satisfactory glucose recovery (97.25–104 %) in serum samples, indicating its potential for future applications in real samples analysis.

电化学葡萄糖传感器对环境及人类健康至关重要，它需要具有优异电化学性能的理性纳米结构以实现葡萄糖的氧化。通过利用氢氧根离子刻蚀镍-二甲基乙二酰肼（DMG）纳米棒，合成了以Ni(DMG)2为部分牺牲模板的Ni(OH)2/Ni(DMG)2复合纳米管。在传统及便携式电化学工作站上，对最佳的Ni(OH)2/Ni(DMG)2非酶葡萄糖传感器进行了评估，该传感器表现出高灵敏度和低检测限。将最优的Ni(OH)2/Ni(DMG)2葡萄糖传感器集成至智能手机中，其检测限低至3.3 µM（M表示摩尔浓度），线性检测范围宽广（10 µM–8 mM），对于葡萄糖检测的灵敏度达到262.80 µA mM−1 cm−2。此外，这些传感器还展现出良好的稳定性和重现性，以及在高尿酸、葡萄糖酸、脯氨酸、NaCl、缬氨酸和赖氨酸等物质存在下的抗干扰能力。此外，便携式传感器在血清样本中也表现出令人满意的葡萄糖回收率（97.25–104 %），预示着其在未来实际样品分析领域的应用潜力。