Data from: Tissue mechanics govern the rapidly adapting and symmetrical response to touch

PLEASE NOTE, THESE DATA WERE ALSO ANALYZED FOR A SUBSEQUENT PUBLICATION in
eLife. PLEASE SEE https://doi.org/10.7554/eLife.43226 FOR MORE
INFORMATION. Recordings from Pacinian corpuscles in the 1960s showed that
touch elicits symmetric activation followed by rapid adaptation.
Sinusoidal stimulation resulted in frequency doubling within a sensitive
frequency band, suggesting that these receptors function as
frequency-tuned vibration sensors. At the time, the surrounding lamellar
capsule was proposed to generate these response dynamics by acting as a
mechanical filter. However, similar response dynamics have since been seen
in many other mechanoreceptors, leading to controversy over the
specificity of this hypothesis. Using a combination of in vivo
electrophysiology, feedback-controlled mechanical stimulation, and
simulation, we resolve this controversy in favor of a systems-level
mechanical filter that is independent of specific anatomical features or
specific mechanoelectrical transduction channels.