The total synthesis of natural (+)-hyacinthacine C5 was achieved, which allowed correction of its initially proposed structure, as well as six additional hyacinthacine C-type compounds. These compound
Campesterol is an important precursor for many sterol drugs, e.g. progesterone and hydrocortisone. In order to produce campesterol in Yarrowia lipolytica, C-22 desaturase encoding gene ERG5 was disrup
Several toll-like receptors (TLRs) reside inside endosomes of specific immune cellsamong them, aberrant activation of TLR7 and TLR9 is implicated in myriad contexts of autoimmune diseases, making the
