Supplementary Material for: Effects of replacing intradialytic parenteral nutrition by oral nutritional supplements and PEPA membrane on nutritional status in maintenance hemodialysis patients with end-stage kidney disease

Introduction: In patients receiving hemodialysis, protein-energy wasting may be frequent and is associated with nutritional and metabolic alterations. This study aimed to describe the effects of a new therapeutic strategy i.e., oral nutritional supplements (ONS) associated with a polyester-polyarylate (PEPA) membrane, on nutritional markers in high-risk patients with IDPN history. Methods: Patients, who received individually IDPN (M-6 to M0) then ONS (M0 to M6), were followed over a 12-month period. Results: There was no change in serum albumin over time. The BMI increased between M-6 and M6. Food intake showed increase between M0 and M3. Quality-of-life score was stable between M0 et M6. None of the adverse events was judged related to ONS, PEPA or research procedure. Conclusion: This study focusing on a new therapeutic strategy composed of ONS and PEPA membrane replacing IDPN to maintain nutritional markers in high-risk patients receiving hemodialysis might warrant further research with robust methodology.