Dataset supporting the publication "Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity"

Dataset supporting the publication "Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity", J. Biol. Chem, 2014, 289, 9340-9351. DOI: 10.1074/jbc.M113.533315 Authors: Faure, L.; Nagarajan, S.; Hwang, H.; Montgomery, C. L.; Khan, B. R.; John, G.; Koulen, P.; Blancaflor, E. B.; Chapman, K. D. The dataset includes the original raw data of the N-Acylethanolamines (NAEs) synthesized (NMR data, Mass spectral data of compounds 5 and 6. i.e. 5, PDP-EA (N-(2-hydroxyethyl)-2-(3-n-pentadecylphenoxy)acetamide); and 6, cardanol-EA (mixture of phenoxyacyl-ethanolamides). Which includes the raw data and graphical plots. Shart Abstract: N-Acylethanolamines (NAEs) are involved in numerous biological activities in plant and animal systems. The metabolism of these lipids by fatty acid amide hydrolase (FAAH) is a key regulatory point in NAE signaling activity. Several active site-directed inhibitors of FAAH have been identified, but few compounds have been described that enhance FAAH activity. Here we synthesized two sets of phenoxyacyl-ethanolamides from natural products, 3-n-pentadecylphenolethanolamide (5) and cardanolethanolamide (6), with structural similarity to NAEs and characterized their effects on the hydrolytic activity of FAAH.