RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells

ChEBI2016-08-22 更新2026-07-12 收录

白血病干细胞

RIPK3信号通路

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-79040 数据链接链接失效反馈

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RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells

创建时间：

2016-08-22

The H3K4-methyl epigenome regulates MLL leukemia stem cell oncogenic potential

白血病干细胞

表观遗传学

The genetic programs that maintain leukemia stem cell (LSC) self-renewal and oncogenic potential have been well defined, however the epigenetic landscape that determines their cellular identity and fu

NIAID Data Ecosystem70

In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [RNA-seq]. In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [RNA-seq]

白血病干细胞

CRISPRi筛选

RNA binding protein (RBP)-directed post-transcriptional control of stem cell fate represents an underexplored mechanism driving hematopoietic stemness and transformation. We show that a unique set of

NIAID Data Ecosystem40

Supplementary Table 3 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

白血病干细胞

肿瘤治疗靶点

XLSX file - 15KB, MicroRNAs differentially expressed between LSC and HSC (at least 2 out of 3 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim(LSC) and CD34+CD38-ALDHhigh (HS

Figshare2014-04-01 更新10

Genome-wide chromatin accessibility profiling of LT-HSCs isolated from WT and Phf6-deficient mice

白血病干细胞

染色质可及性

The plant homeodomain 6 gene (PHF6) is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL); however, its specific functional role in leukemia development remains to be established.

NIAID Data Ecosystem60

Supplementary Data for "Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance"

白血病干细胞

化疗耐药机制

We performed functional genomic profiling of diverse leukemias using label tracing techniques. We identified AML stem cell quiescence is defined by distinct promoter-centered chromatin and gene expres

Zenodo2025-01-03 更新20

RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells

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