Comparison with gene expression profile of young and aged muscle progenitor cells

Frailty of the locomotory organs has become a widespread problem in the geriatric population. The major factor leading to frailty is an age-associated decrease in muscular mass and a reduced number of muscular cells and myofibers. To understand why decrease self-renew at he gene expression profile the diffeerences between aged and young Muscle progenitor cells(MPSCs). In aged muscular tissues, muscle progenitor cells(MPSCs) are reduced due to abnormalities in their self-renewal and the induction of apoptosis. However, the molecular mechanisms connecting aging-associated physiological changes and the reduction of MPSCs are largely unknown. In this study, we compared the gene expression profile of young and aged MPSCs to identify genes involved in the reduction of MPSCs. Muscle progenitor cells( MPSCs) (CD29+/ITGA7+) were isolated from young (5 weeks old) and aged (2 years old) C57Bl/6 mice.