Distribution of HPV genotype profile in juvenile and adult onset RRP, n (%) (N = 221).

The difference in HPV profile between juveniles and adults was significant (p = 0.010). *Including one patient with adult-onset RRP who tested HPV 8 positive in metagenomic sequencing. ΔInfection with both HPV 6 and 11. §HPV 6 or 11(LR HPV) in co-infection with one or two high-risk HPV types (HR HPV). High-risk HPV types (HR HPV) comprised HPV 33, 45, 18, 16, 31 or 35.