Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple negative breast cancer. Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple negative breast cancer

Apigenin reprogrammes the transcriptome of TNBC through alternative splicing thereby exerting anti-proliferative and pro-apoptotic activities. Our findings underscore the potential impact of nutraceuticals for improved TNBC prevention and treatment. Overall design: Comparative alternative splciing analyses of RNA-seq data for triple negative breast cancer MDA-MB-231 cells treated with vehicle or apigenin (DMSO, Api). Twp biological replicates analyzed for both conditions.