Profiling of the Circulating MiRNome in Pediatric Egyptian Patients with Wilms Tumor

The current study comprehensively profiled miRNA expression patterns in the serum of WT patients using NGS to explore their potential to discriminate WT patients with favorable histology from those with unfavorable histology and assessed their potential as minimally invasive biomarkers for WT detection. The study also evaluated key pathways and biological processes affected by these dysregulated miRNAs, providing insights into the underlying mechanisms driving tumorigenesis in WT.