Spontaneous lung fibrosis resolution reveals novel anti-fibrotic regulators
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Fibroblast activation is transient in successful wound repair, but persistent in fibrotic pathologies. Understanding fibroblast deactivation during successful wound healing may provide new approaches to therapeutically reverse fibrogenic cell activation. To characterize the gene programs that accompany fibroblast activation and reversal during lung fibrosis resolution, we used RNA-seq analysis of flow sorted Col1α1-GFP positive and CD45, CD31, and CD326 negative cells isolated from the lungs of young mice exposed to bleomycin. We compared fibroblasts isolated from controls to those isolated at days 14 and 30 after bleomycin exposure, representing the peak of extracellular matrix deposition and an early stage of fibrosis resolution, respectively.
提供机构：
Mayo Clinic
创建时间：
2022-02-20
