Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-2-cyano-N-[4-(3-fluorophenyl)-5-methylsulfonylpyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide

Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-2-cyano-N-[4-(3-fluorophenyl)-5-methylsulfonylpyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide Descriptor: (2Z)-2-cyano-N-[(4P)-4-(3-fluorophenyl)-5-(methanesulfonyl)pyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. Deposit date: 2023-02-08 Release date: 2024-02-21 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (1.79 Å) Cite: Crystal Structure of a human cyclic GMP-AMP synthase complex To be published

人类环GMP-AMP合酶（cyclic GMP-AMP synthase）与(Z)-2-氰基-N-[4-(3-氟苯基)-5-甲磺酰基嘧啶-2-基]-3-羟基-3-(5-甲基-1,2-恶唑-4-基)丙-2-烯酰胺复合物的晶体结构
组分描述：(2Z)-2-氰基-N-[(4P)-4-(3-氟苯基)-5-(甲磺酰基)嘧啶-2-基]-3-羟基-3-(5-甲基-1,2-恶唑-4-基)丙-2-烯酰胺、1,2-乙二醇（1,2-ETHANEDIOL）、腺苷-5'-三磷酸（ADENOSINE-5'-TRIPHOSPHATE）等
作者：Leibrock, L、Benz, J、Groebke-Zbinden, K、Rudolph, M.G.
沉积日期：2023-02-08
发布日期：2024-02-21
最后修改日期：2026-02-18
测试方法：X射线衍射（1.79 Å）
引用文献：《人类环GMP-AMP合酶复合物的晶体结构》，待发表