High-Confidence Pemivibart (VYD2311) Escape Haplotypes in U.S. SARS-CoV-2 Sequences, Span 2023 - 2024
收藏DataCite Commons2025-12-20 更新2026-04-25 收录
下载链接：
https://figshare.com/articles/dataset/High-Confidence_Pemivibart_VYD2311_Escape_Haplotypes_in_U_S_SARS-CoV-2_Sequences_Span_2023_-_2024/30927926/1
下载链接
链接失效反馈官方服务：
资源简介：
This dataset documents nine U.S.-derived SARS-CoV-2 isolates (<b>8 from Puerto Rico</b>, <b><i>1 from Michigan</i></b>) collected in late 2023 early 2024 that carry high-confidence escape constellations against the monoclonal antibody pemivibart (VYD2311). All nine sequences harbor ≥4 of the five canonical resistance mutations (R346T, S371F, K444T, F456L, F486P) and were identified through the <b>Pemivibart Structural Vulnerability Index</b> (<b>PSVI</b>). Includes full spike amino acid sequences, metadata, PyMOL visualization scripts, and Python code for composite figure generation. This evidence demonstrates that pemivibart resistance was genetically encoded in circulating U.S. lineages prior to the antibody’s Emergency Use Authorization (March 2024).Study by: Tahir HB<br>
提供机构：
figshare
创建时间：
2025-12-20
