Table 1 in Assessment of FDA-approved drugs against StrongyloideS rAtti in vitro and in vivo to identify potentially active drugs against strongyloidiasis

Table 1 In vitro activity of hits against S. ratti L3 and adults DrugEffect on L3 (% dead after 72 h), [SD (%)] at 100 µMEffect on adult worms (% dead after 72 h), [SD (%)] at 10 µMDrugindication dAconitine88.1 (7.5)17.4 (5.1)Anesthetic (gastric), antipyretic, and cardiotoxinAcriflavinium HCl79.4 (7.7)97.7 (2.3)Anti-infective, intercalating agentAmantadine HCl75.5 (8.2)24.1 (4.0)Antiviral, antiparkinsonian; treatment of drug-induced extrapyramidal reactionsAminohippuric acid84.8 (6.3)32.7 (10.2)Renal function diagnosisBenzethonium chloride100.0 (0)100.0 (0)Anti-infective (topical)Bitoscanate100.0 (0)16.5 (6.4)AnthelminticBrinzolamide82.7 (4.0)20.1 (11.4)AntiglaucomaCaptamine91.0 (4.6)35.1 (9.9)Depigmenting agentCetylpyridinium chloride100.0 (0)100.0 (0)Anti-infective (topical)Ceftriaxone sodium trihydrate100.0 (0)20.6 (11.9)AntibacterialCetrimonium bromide100.0 (0)77.3 (11.4)Anti-infectiveChlormidazole93.3 (5.1)88.6 (11.4)AntifungalChloroxylenol88.3 (2.2)64.6 (35.4)Antibacterial, topical, and urinary antisepticChlorpyrifos100.0 (0)73.1 (18.8)InsecticideCinnarizine94.7 (1.0)59.6 (40.06)H1 antihistamineCoumaphos100.0 (0)100.0 (0)Insecticide, cholinesterase inhibitorCyproheptadine HCl100.0 (0)31.3 (3.7)H1-antihistamine, antipruriticDactinomycin71.4 (6.4)41.7 (10.4)Antineoplastic, intercalating agentDebrisoquin sulfate91.3 (1.5)8.85 (1.3)Anti-hypertensiveDemeclocycline HCl81.5 (4.0)–AntibacterialDyclonine HCl100.0 (0)29.6 (9.5)Anesthetic (topical)Dibenzothiophene90.8 (2.8)13.2 (6.9)KeratolyticDimpylate100.0 (0)85.6 (15.0)Insecticide,cholinesterase inhibitorEbselen96.6 (1.9)52.5 (13.4)Antioxidant,lipoxygenase inhibitor, inhibits oxidation of LDLEdoxudine89.8 (3.7)27.2 (7.1)AntiviralEnilconazole sulfate71.0 (7.9)21.9 (3.1)AntifungalEnoxacin85.4 (2.9)44.6 (9.6)AntibacterialEthisterone100.0 (0)52.4 (24.6)ProgestogenFenthion100.0 (0)87.0 (11.3)Insecticide, ectoparasiticideFloxuridine88.9 (2.1)62.6 (37.5)Antineoplastic, antimetaboliteGallamine triethiodide88.5 (2.9)43.1 (11.3)Muscle relaxant (skeletal)Gentian violet100.0 (0)100.0 (0)Antibacterial,anthelminticGramicidinb72.7 (2.0)32.9 (10.1)AntibacterialHalcinonide96.1 (0.9)38.7 (4.3)Glucocorticoid,anti-inflammatoryHexylresorcinol83.6 (3.2)28.8 (8.7)Anthelmintic,topical antisepticHycanthone78.0 (15.0)29.3 (13.5)Anthelmintic,hepatotoxicHydrocortisone butyrate77. 8 (4.0)54.3 (20.4)Glucocorticoid,anti-inflammatoryImiquimod HCl80.6 (9.2)64.4 (24.3)ImmunomodulatorIndapamide70.1 (6.0)36.6 (16.5)Diuretic, antihypertensiveInositol75.9 (4.1)28.9 (8.9)Growth factorIodoquinol70.8 (5.1)17.9 (2.2)Anti-amoebicIsoxicam89.5 (2.8)19.3 (3.6)Anti-inflammatoryIvermectin100.0 (0)8.9 (1.25)AntiparasiticKanamycin A sulfate71.0 (3.1)50.9 (7.0)AntibacterialLabetalol HCl79.9 (8.3)41.0 (13.2)Adrenergic blockerLasalocid sodium88.7 (1.6)10.9 (12.0)AntibacterialLevamisole HCl93.1 (4.5)88.6 (11.4)Immunomodulatory, anthelminticMalathion100.0 (0)–Pediculicide, insecticide, cholinesterase inhibitorMegestrol acetate73.3 (5.54)51.4 (2.92)Progestogen, antineoplasticMethylbenzethonium chloride91.5 (1.4)100.0 (0)cAnti-infectiveMethylthiouracil100.0 (0)34.3 (14.2)Antithyroid agentMianserin HCl100.0 (0)19.6 (6.9)5HT antagonistMitoxantrone HCl92.6 (9.8)39.8 (3.1)AntineoplasticMorantel citrate100.0 (0)100.0 (0)AnthelminticNadolol84.6 (5.8)52.5 (17.5)Beta-adrenergic blockerNiclosamide76.3 (15.2)–Anthelmintic,teniacideNorethynodrel100.0 (0)36.8 (5.3)Progestogen, in combination with estrogen as oral contraceptiveOxethazaine82.9 (6.34)–Anesthetic (local)Phenothiazine93.3 (0.8)37.1 (2.2)AnthelminticPrasterone acetate88.6 (7.7)77.1 (22.8)Adrenocortical hormone, antidepressantPrednicarbate100.0 (0)29.9 (13.2)Anti-inflammatory,glucocorticoidPrilocaine HCl88.5 (2.2)25.1 (5.1)Anesthetic (local)Proadifen HCl74.9 (4.8)21.3 (1.2)Cytochrome P450 inhibitor, Ca antagonist,anesthetic (local)Propiolactone92.8 (2.0)49.5 (4.81)Anti-infectivePyrantel pamoate100.0 (0)53.0 (32.9) 52.9 (3.9)aAnthelminticSelamectin79.9 (8.1)–Anthelmintic, antiparasitic, anti-miteSulfanitran100.0 (0)65.7 (24.8)cAntibacterial, coccidiostatTerpene hydrate70.5 (16.6)18.4 (4.5)ExpectorantTetroquinone85.4 (4.9)42.9 (11.4)cKeratolyticTriflupromazine HCl90.6 (5.6)–AntipsychoticTylopaxol84.1 (8.3)43.8 (11.2)Polymeric nonionic detergent Hits are defined as compounds with 70% activity against S.ratti L3 a Considering salt factor (29 µM),empty cells reflect missing drug b Gramicidin A (87%),B (7%),C (5%),and D (1%) ex Bacillus brevis c Only tested once.SD was calculated between individual wells d Indication according to library provider (Pharmakon)