GDP-bound KRAS G12D in complex with TH-Z827
收藏Protein Data Bank Japan2023-11-29 更新2026-03-21 收录
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GDP-bound KRAS G12D in complex with TH-Z827 Descriptor: 4-[(1~{R},5~{S})-3,8-diazabicyclo[3.2.1]octan-8-yl]-7-(8-methylnaphthalen-1-yl)-2-[[(2~{S})-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidine, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... Authors: Shen, P, Yang, Y, Yang, Y, Zhang, L, Chen, C.-C, Guo, R.-T. Deposit date: 2021-05-25 Release date: 2021-12-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.25 Å) Cite: KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov, 8, 2022
创建时间：
2021-05-25
