TBP2 gene may not be associated with primary ovarian insufficiency

<b>Objective:</b> It has previously been reported that TATA-binding protein 2 (TBP2) knockout female mice are sterile. Our objective was to assess the association between the TBP2 gene and primary ovarian insufficiency (POI) in a Chinese population. <b>Methods:</b> A cohort of 60 POI patients matched with 60 fertile controls was recruited by Nanjing Medical University. There were no interventions. The complete TBP2 exon regions were analyzed by direct sequencing in all POI patients and controls. <b>Results:</b> A known single nucleotide polymorphism (rs8019270) was identified in both POI and control groups. There was no difference in the genotype distribution or allelic frequencies between the control group and the POI group. No plausible pathogenic mutations were identified. <b>Conclusion:</b> Our study indicates that the TBP2 gene is not responsible for idiopathic POI in the Chinese Han population.