Crystal structure of human chitotriosidase-1 (hChit1) catalytic domain in complex with compound 2-8-14

Crystal structure of human chitotriosidase-1 (hChit1) catalytic domain in complex with compound 2-8-14 Descriptor: 6-azanyl-2-oxidanylidene-N-[(1S)-1-phenylethyl]-7-(phenylmethyl)-1$l^{4},9-diaza-7-azoniatricyclo[8.4.0.0^{3,8}]tetradeca-1(14),3(8),4,6,10,12-hexaene-5-carboxamide, Chitotriosidase-1 Authors: Jiang, X, Yang, Q. Deposit date: 2019-02-26 Release date: 2020-02-19 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.834 Å) Cite: A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors. J.Med.Chem., 63, 2020人源几丁质酶-1（human chitotriosidase-1, hChit1）催化结构域与化合物2-8-14结合的晶体结构 配体描述：6-氨基-2-氧代-N-[(1S)-1-苯乙基]-7-(苯甲基)-1λ⁴,9-二氮杂-7-氮鎓三环[8.4.0.0³,⁸]十四碳-1(14),3(8),4,6,10,12-六烯-5-甲酰胺 作者：Jiang, X、Yang, Q 提交日期：2019-02-26 发布日期：2020-02-19 最后修改日期：2024-11-20 检测方法：X射线衍射（分辨率1.834 Å） 引用文献：《一类含二吡啶并嘧啶骨架的化合物作为新型人源与害虫几丁质酶抑制剂》，J.Med.Chem., 63, 2020