Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [WGBS]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE98186
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资源简介：
Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs. Dnmt3a-null system cells transplanted multiple times in mice were sequenced for RNA-Seq, ChIP-Seq, and methylation using Illumina Nextseq
创建时间：
2021-07-25
