Comparing transcriptomes of wild-type, hyperfilamentous, and hypofilamentous biofilms in S. cerevisiae

Purpose was to identify common and unique genes regulated by the following filamentous growth regulators: Dig1, Ste12, Ras2, Rtg3, Spt8. By harvesting cells from various biofilms we attempted to identify major regulatory targets that underpin biofilm/mat formation in fungi.本研究的核心目标为鉴定受下述丝状生长调控因子（filamentous growth regulators）调控的共有与特有基因，所涉调控因子包括Dig1、Ste12、Ras2、Rtg3及Spt8。本研究通过从多种生物被膜（biofilm）中收集细胞，旨在鉴定支撑真菌生物被膜/基质形成的关键调控靶点。