1.85 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor (analog 13)

1.85 A resolution structure of WT BfrB from Pseudomonas aeruginosa in complex with a protein-protein interaction inhibitor (analog 13) Descriptor: 4-{[3-(4-hydroxyphenyl)propyl]amino}-1H-isoindole-1,3(2H)-dione, FE (II) ION, Ferroxidase, ... Authors: Lovell, S, Punchi-Hewage, A, Battaile, K.P, Yao, H, Nammalwar, B, Gnanasekaran, K.K, Bunce, R.A, Reitz, A.B, Rivera, M. Deposit date: 2019-01-08 Release date: 2019-05-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Small Molecule Inhibitors of the BfrB-Bfd Interaction Decrease Pseudomonas aeruginosa Fitness and Potentiate Fluoroquinolone Activity. J.Am.Chem.Soc., 141, 2019

1.85 Å分辨率的铜绿假单胞菌（Pseudomonas aeruginosa）野生型BfrB与蛋白-蛋白相互作用抑制剂（类似物13）的复合物晶体结构。描述符：4-{[3-(4-羟基苯基)丙基]氨基}-1H-异吲哚-1,3(2H)-二酮、亚铁（Fe(II)）离子、铁氧化酶（Ferroxidase）…… 作者：Lovell, S、Punchi-Hewage, A、Battaile, K.P、Yao, H、Nammalwar, B、Gnanasekaran, K.K、Bunce, R.A、Reitz, A.B、Rivera, M。沉积日期：2019-01-08；发布日期：2019-05-08；最后修改日期：2023-10-11。实验方法：X射线衍射（X-RAY DIFFRACTION，1.85 Å）。引用文献：《靶向BfrB-Bfd相互作用的小分子抑制剂可降低铜绿假单胞菌生存适应性并增强氟喹诺酮类药物活性》，J.Am.Chem.Soc., 141卷, 2019年。