Properties of observed deletions in the meta-controls versus randomly placed simulated deletions.

Here we compare the observed properties for rare deletions in meta-controls to that of 1000 simulated random segments, matched for size and probe-density. For simulated random deletions for each property, we list the median value, and in parentheses we list the 95% range. We have noted values from observed deletions that deviate (p<0.05) from the simulations with asterisks (*). The first set of values compare observed rare deletions to random segments. The number and median length are the same since segments were matched for these properties. In the next two lines we list the numbers of overlapping and disrupted genes. The next set of values compare data on the set of genes overlapping observed deletions to simulated segments. We list the number of overlapping genes altogether, and exceeding specific gene length thresholds (100 kb, 500 kb, and 1 Mb). Finally we list the odds ratio for the three brain-function gene sets for the set of overlapping genes. The final set of values compare similar data on the set genes disrupted by rare deletions to simulated segments. Disrupted genes stratified by length is not shown, and is similar to that of overlapping genes.