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Characterization of the var gene associated GC-rich non-coding RNA in Plasmodium falciparum

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NIAID Data Ecosystem2026-04-25 收录
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In this study we characterized the GC-rich non-coding RNA (gcRNA) which is located upstream of central var genes in the human malaria parasite Plasmodium falciparum. We knocked-down the gcRNA using CRISPRi and assessed transcriptomic changes using stranded RNA seq. Positive binding of the dCas9 protein to the target locus was characterized by dCas9-ChIP seq

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2019-12-26
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