Relevant calculated populations and maximal contact lifetimes between linker and TI loop residues.

Relation of connected and broken states (population) and maximal contact lifetimes for each interaction during the whole simulation of 50 ns are listed. For determining the population, the existence of a contact was checked in 100-ps-steps. Thus, the total number of possible states is 500. For the contact definition, a cut-off sphere of 3.5 Å is used. Beyond this value, a contact is defined as broken.