Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with (6'-hydroxy-1'-(4-(2-(1-propylpyrrolidin-3-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with (6'-hydroxy-1'-(4-(2-(1-propylpyrrolidin-3-yl)ethoxy)phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone Descriptor: Estrogen receptor, [(1'R)-6'-hydroxy-1'-(4-{[(3R)-1-propylpyrrolidin-3-yl]methoxy}phenyl)-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone Authors: Young, K.Y, Fanning, S.W. Deposit date: 2024-05-09 Release date: 2024-06-19 Last modified: 2025-01-29 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells. Breast Cancer Res, 27, 2025

雌激素受体α（Estrogen Receptor Alpha）配体结合域Y537S突变体与(6'-羟基-1'-(4-(2-(1-丙基吡咯烷-3-基)乙氧基)苯基)-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基)(苯基)甲酮的复合物。
描述：雌激素受体，[(1'R)-6'-羟基-1'-(4-{[(3R)-1-丙基吡咯烷-3-基]甲氧基}苯基)-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基](苯基)甲酮
作者：Young, K.Y.、Fanning, S.W.
提交日期：2024-05-09
发布日期：2024-06-19
最后修改时间：2025-01-29
实验方法：X射线衍射（分辨率1.98 Å）
引用文献：靶向独特配体结合域结构特征下调Y537S ESR1突变乳腺癌细胞中的DKK1，《乳腺癌研究（Breast Cancer Res）》，27卷，2025年