Obesity regulates the fate of peripheral blood mononuclear cells through FoxM1

Obesity is associated with various diseases such as metabolic disorders, joint problems, and inflammations. Over 50% of pets, including dogs and cats, are obese, making a comparative study necessary at gene level. Since circulating peripheral blood mononuclear cells (PBMCs) reflect the organs related to obesity, we compared the mRNA expression in normal and obese PBMCs of dogs. Our findings show that there are 425 differentially expressed genes (DEGs) (p < 0.05, |log2 fold| ≥ 1) that exhibit distinct gene expression between normal and obese PBMCs. In Kyoto encyclopedia of genes and genomes (KEGG) and Ingenuity Pathway Analysis (IPA) indicate that obesity affect the PBMC cell cycle through FoxM1. These results suggest that obesity causes functional change of PBMCs through cell cycle regulation. In conclusion, obesity suppresses the PBMCs-mediated immune response through FoxM1. To compare DEG profiles of PBMCs between normal dogs and obese dogs