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High-Content Screening Identifies A Small Molecule That Restores AP-4-dependent Protein Trafficking In Neuronal Models Of AP-4-Associated Hereditary Spastic Paraplegia

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA985061
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The goal of this study is to identify transcriptomic changes in AP4B1-WT vs. AP4B1-KO SH-SY5Y cells following treatment with compound BCH-HSP-C01. This lead compound was identified in a phenotypic cell based high-throughput screen by Saffari et al. The title of the study is: "High-Content Screening Identifies A Small Molecule That Restores AP-4-dependent Protein Trafficking In Neuronal Models Of AP-4-Associated Hereditary Spastic Paraplegia
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2023-06-18
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