Human Plasma Proteome During Normal Pregnancy

This study used SomaScan v 4.1 to profile>7000 proteins in maternal plasma and asses changes with gestational age and maternal characteristics. The study proposed models to estimate the expected protein abundance so that future datasets can be normalized agains these expected value to obtain Multiples of the Mean values. This is a longitudinal study that included typically 6 samples collected throughout gestation from women who had an uncomplicated pregnancy.