Effect of I148M PNPLA3 variant on clinical presentation of HCC according to the etiology of liver disease (ALD & NAFLD vs. other etiologies).

(): % values, {}: median and interquartile range. HCC: hepatocellular carcinoma, ALD: alcoholic liver disease, NAFLD: nonalcoholic fatty liver disease, F: female, PNPLA3: patatin-like phosholipase domain-containing 3. °Additive model. * Available in 353 patients, ** available in 413 patients. Very early HCC and advanced / terminal HCC were defined according to the updated Barcelona Clinic Liver Cancer (BCLC) staging system and EASL/EORTC guidelines [1].