Risk profile estimates for phenotypes of interest.

Abbreviations: RG; Reference Group, AUC; area under the curve, OR; Odds Ratio, CI; Confidence Interval.*Denotes models could not be fit accurately due to only 40 cardioembolic cases, although the overall risk profile trend was significant (Beta = 6.58, Standard error = 1.99, p-value = 0.000936).#Denotes analysis with reference group as the quintile possessing the fewest alleles associated with earlier onset stroke, as an example, the 5th quintile is the group comprised of participants with the highest cumulative allele dosages associated with earlier onset stroke, mean ages at onset per quintile as follows from 1st to 5th quintiles: 77.51, 69.09, 67.23,66.82, and 63.08 years.Estimated risk per allele was scaled based on effect estimates from the ISGS/SWISS dataset and fitted to the BRAINS dataset, with nominated SNPs including all SNPs meeting a p-value threshold of 10−5 in the meta-analysis specific to each phenotype.