Effect of salinity change on miRNA expression in scales of Oncorhynchus mykiss

Fish skeleton (bones and cartilage) is intimately linked to muscle growth, and is essential for multiple physiological functions such as development, locomotion and load bearing. Similar to the other vertebrates, fish skeleton represents a reservoir of ions such as calcium (Ca), phosphorus (P), and etc., which are in a state of continual exchange with electrolytes found in blood and extracellular fluids. As a complex metabolically active tissue, fish bones undergo continuous remodeling throughout their life. More importantly, bone also plays an important role in plasma ion homeostasis. Previous researches have also demonstrated the importance of linking physiology to biomineral processes. However, the potentially impact of salinity change on bone homeostasis in rainbow trout is unclear.