Integrative transcriptome and proteome revealed high-yielding mechanisms of epsilon-poly-L-lysine by Streptomyces albulus

epsilon-poly-L-lysine is a high value, widely used natural antimicrobial peptide additive for foods and cosmetic products that is mainly produced by S. albulus. In previous work, we developed the high-yield industrial strain S. albulus WG-608 through successive rounds of engineering. Here, we use integrated physiological, transcriptomic, and proteomics association analysis to resolve the complex mechanisms underlying high epsilon-poly-L-lysine production by comparing WG-608 with the progenitor strain M-Z18. This study enables comprehensive understanding of the biosynthetic mechanisms of epsilon-poly-L-lysine in S. albulus WG-608, while providing a theoretical foundation development of advanced Streptomycetaceae microbial cell factories.