Structure of human endothelial nitric oxide synthase heme domain in complex with 4-((4-(2-Amino-4-methylquinolin-7-yl)-2-(aminomethyl)phenoxy)methyl)benzonitrile

Structure of human endothelial nitric oxide synthase heme domain in complex with 4-((4-(2-Amino-4-methylquinolin-7-yl)-2-(aminomethyl)phenoxy)methyl)benzonitrile Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-{[2-(aminomethyl)-4-(2-amino-4-methylquinolin-7-yl)phenoxy]methyl}benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, ... Authors: Chreifi, G, Li, H, Poulos, T.L. Deposit date: 2019-07-05 Release date: 2020-04-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.02 Å) Cite: First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020

人类内皮型一氧化氮合酶血红素结构域与4-((4-(2-氨基-4-甲基喹啉-7-基)-2-(氨甲基)苯氧基)甲基)苯甲腈的复合物晶体结构。配体组分：2-[双(2-羟乙基)氨基]-2-羟甲基丙烷-1,3-二醇、4-{[2-(氨甲基)-4-(2-氨基-4-甲基喹啉-7-基)苯氧基]甲基}苯甲腈、5,6,7,8-四氢生物蝶呤……。作者：Chreifi G、Li H、Poulos TL。沉积日期：2019-07-05，发布日期：2020-04-29，最后修改日期：2023-10-11。解析方法：X射线衍射（分辨率2.02埃）。引用文献：《7-苯基-2-氨基喹啉类：靶向亚型特异性天冬氨酸的强效选择性神经元一氧化氮合酶抑制剂》，《药物化学杂志》（J. Med. Chem.），2020年，第63卷。