Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine (DX3)
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Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine (DX3) Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 6,7,7-trimethyl-7,8-dihydropteridine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Tulloch, L.B, Hunter, W.N. Deposit date: 2009-09-06 Release date: 2009-12-08 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases. J.Med.Chem., 53, 2010
布氏锥虫（Trypanosoma brucei）来源的蝶啶还原酶1（pteridine reductase 1, PTR1）与辅酶烟酰胺腺嘌呤二核苷酸磷酸（nicotinamide adenine dinucleotide phosphate, NADP+）以及抑制剂6,7,7-三甲基-7,8-二氢蝶啶-2,4-二胺（DX3）形成三元复合物的晶体结构。配体描述：2,3-二羟基-1,4-二硫代丁烷、6,7,7-三甲基-7,8-二氢蝶啶-2,4-二胺、烟酰胺腺嘌呤二核苷酸磷酸（NADP）……。作者：Tulloch, L.B.、Hunter, W.N.。存档日期：2009-09-06；发布日期：2009-12-08；末次修改日期：2023-09-06。测定方法：X射线衍射（1.95埃）。引用文献：《针对非洲昏睡病与利什曼病的蝶啶还原酶抑制剂的基于结构设计》，《药物化学杂志》（J.Med.Chem.），第53卷，2010年
创建时间：
2009-09-06
