Exosomal MicroRNAs modulates the cognitive function in Fasudil treated APP/PS1 Transgenic Mouse model of Alzheimer's disease

AD is characterized by cognitive impairment caused by the accumulation of beta-amyloid plaques and trans-synaptic spread of tau pathology. Exosome has emerged as key mediators for neuronal development, maintenance, and cellular communication. However, the molecular mechanism of exosomal miRNAs related to AD remains unknown. In the present study, mice were treated with vehicle and fasudil . Exosomal RNAs from each mouse of the group were extracted, sequenced and analyzed.