55 screening positives and their involvement in other cellular stress pathways.

Qualitative analyses of GFP induction (by stereomicroscopy) of the different stress reporters with their respective inducers. UPRmt (paraquat): induction of the hsp-6 reporter (Phsp-6::gfp) with paraquat; phase II response: SKN-1 dependent induction of the gst-4 reporter (Pgst-4::gfp) with acrylamide; UPRcyt: induction of the hsp-16.2 reporter (Phsp-16.2::gfp) with heat shock; UPRER: induction of the hsp-4 reporter (Phsp-4::gfp) with tunicamycin; UPRmt (zc32): induction of the hsp-60 reporter (Phsp-60::gfp) in the zc32 ts-mutant at the restrictive temperature. +: GFP induced; off: GFP not induced; n.d.: not determined;*: in two out of three experiments; assessed by qualitative compound microscopy. Group assignment of individual candidates is based on DAVID gene enrichment analyses [56].