New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives

New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives Descriptor: 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V, Pace, J, Chisum, K, Rosowsky, A. Deposit date: 2006-02-09 Release date: 2006-12-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins, 65, 2006

《二氢叶酸还原酶（DHFR，Dihydrofolate reductase）相互作用新进展：卡氏肺孢子虫与小鼠二氢叶酸还原酶结合烟酰胺腺嘌呤二核苷酸磷酸（NADPH，Dihydro-Nicotinamide-Adenine-Dinucleotide Phosphate）及两种强效甲氧苄啶衍生物的复合物分析》
描述项：2,4-二氨基-5-[3',4'-二甲氧基-5'-(5-羧基-1-戊炔基)]苄基嘧啶（2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE）、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）
作者：Cody, V.、Pace, J.、Chisum, K.、Rosowsky, A.
提交日期：2006年2月9日
发布日期：2006年12月26日
最后修改日期：2023年8月30日
实验方法：X射线衍射（分辨率2 Å）
引用文献：Cody V, Pace J, Chisum K, Rosowsky A. 二氢叶酸还原酶相互作用新进展：卡氏肺孢子虫与小鼠二氢叶酸还原酶结合烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及两种强效5-(ω-羧基(烷氧基)甲氧苄啶衍生物)的复合物分析揭示了活性相关构象关联与新型平行环堆叠相互作用[J]. Proteins, 65, 2006