Binding of two substrate analogue molecules to dihydroflavonol 4-reductase alters the functional geometry of the catalytic site

Binding of two substrate analogue molecules to dihydroflavonol 4-reductase alters the functional geometry of the catalytic site Descriptor: 3,5,7,3',4'-PENTAHYDROXYFLAVONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, dihydroflavonol 4-reductase Authors: Trabelsi, N, Petit, P, Granier, T, Langlois d'Estaintot, B, Delrot, S, Gallois, B. Deposit date: 2008-01-15 Release date: 2008-10-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols Acta Crystallogr.,Sect.D, D64, 2008

两种底物类似物分子与二氢黄酮醇4-还原酶（dihydroflavonol 4-reductase）结合后，会改变该酶催化位点的功能几何构型。数据集组分：3,5,7,3',4'-五羟基黄酮（3,5,7,3',4'-PENTAHYDROXYFLAVONE）、烟酰胺腺嘌呤二核苷酸磷酸（NADP，NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）、二氢黄酮醇4-还原酶（dihydroflavonol 4-reductase）。作者：Trabelsi, N、Petit, P、Granier, T、Langlois d'Estaintot, B、Delrot, S、Gallois, B。提交日期：2008-01-15。发布日期：2008-10-21。最后更新：2024-02-21。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.9 Å。引用文献：《黄酮醇抑制葡萄源二氢黄酮醇4-还原酶的结构证据》，刊载于《Acta Crystallogr.,Sect.D》第D64卷，2008年。