HCT intersection: IAV vs pathway node family (transcriptomic) – all families

This network computes overlap between IAV high confidence transcriptional targets (HCTs) and HCTs of pathway node families derived from SPP transcriptomic consensomes.
METHODS
HCTs are defined as human genes in the 95th percentile of either 1) a viral infection transcriptomic consensome or 2) a pathway node (or node family) consensome.
For an introduction to consensome analysis please refer to Ochsner et al. (2019) Nat Sci Data 6, 252.
We computed four viral infection HCT gene sets (SARS-CoV-1, SARS-CoV-2, MERS and IAV) against HCTs derived from transcriptomic consensomes for pathway receptor and enzyme families. Overlaps between virus infection and node family HCTs were assigned an FDR-corrected q-value, which corresponds to the probability that the degree of overlap is due to a random event. Node family HCT overlaps are ranked in ascending order of q-value.
INTERPRETATION
Cellular signaling pathway node families in this network are organized according to SPP’s signaling pathway node-centric classification, which classifies nodes as receptors, enzymes, transcription factors, ion channels or co-nodes (Ochsner et al., 2019). Node families (circles) are colored according to the category to which they belong: orange = receptors; blue = enzymes; green = transcription factors; mustard = ion channels; grey = co-nodes. Families are grouped by classes (white circles) specific to each category. Node family circle sizes are proportional to the overlap q-value: the larger the node family circle, the lower the q-value and the greater the confidence of the overlap between HCTs for this node family and the viral infection. Clicking a node family will pull up a pane showing details on the data point, including the number of genes in the intersection of its HCTs and those of the viral infection.