Comparing autofluorescence endoscopy and white light video endoscopy for surveillance of patients with familial colorectal cancer.

Interventions: Colonoscopic surveillance with both WLE and AFE in high risk patients (Lynch syndrome or familial colorectal cancer). In case of the detection of colorectal lesions (adenoma, colorectal cancer or hyperplasia) these lesions were removed by polypectomy. AFE was compared to WLE (active control) with respect to the diagnostic yield (detection of colorectal lesions).
Primary outcome(s): The difference between WLE and AFE for detection of adenomatous lesion or CRC during colonoscopy in patient with HNPCC or familial CRC.
Study Design: Non-randomized controlled trial, Open (masking not used), Active, Crossover